Enfamil Optimum (Enspire), Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin and Brain-Supporting DHA Baby Formula, Powder 20.5 Oz Tub
$46.87
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Price: $46.87
(as of Nov 13, 2025 01:33:05 UTC – Details)
Give your baby a great start with Enfamil Optimum—our most advanced formula designed to support immune health and brain development, inspired by the composition of breast milk. Enfamil Optimum, formerly known as Enfamil Enspire Optimum, is our closest baby formula to breast milk. It has lactoferrin, a key immune-supporting protein also found in colostrum and breast milk. It also has a dual HMO blend—2′-FL and LnNT—two of the most abundant human milk oligosaccharides (HMOs) naturally found in breast milk, to help nourish your baby’s immune system. It has brain-building DHA and is made without artificial growth hormones*, artificial colors, or flavors, Enfamil Optimum is a non-GMO† option for parents seeking premium infant nutrition through 12 months of age. Whether you’re combo feeding or transitioning from breastfeeding, this formula offers both peace of mind and convenience for growing families. Join Enfamil Family Beginnings® to earn rewards with every purchase and access exclusive benefits and support. SNAP eligible.
Is Discontinued By Manufacturer : No
Product Dimensions : 4.4 x 6.3 x 5.5 inches; 1.28 Pounds
Manufacturer recommended age : 0 – 1 years
Item model number : 157401
Date First Available : January 21, 2016
Manufacturer : Mead Johnson Nutrition
ASIN : B01ASIEJPA
Best Sellers Rank: #806 in Baby (See Top 100 in Baby) #16 in Powder Baby Formula
Customer Reviews: 4.8 4.8 out of 5 stars 4,412 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
NEW LOOK, SAME PREMIUM NUTRITION: Previously known as Enspire Optimum, Enfamil Optimum Baby Formula now has a refreshed look and name while offering the same trusted infant nutrition parents rely on.
OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum is the first and only leading baby formula to include lactoferrin, a key immune-supporting protein found in colostrum and breastmilk.
SUPPORTS IMMUNE & BRAIN DEVELOPMENT: This premium formula includes lactoferrin, a dual prebiotic blend (2’FL & LnNT), and brain-building DHA—all clinically-tested ingredients.
COMPLETE NUTRITION FOR DAILY FEEDINGS: A great choice for everyday formula use, this 30 oz tub of Enfamil Optimum provides complete nutrition in a convenient powder format—perfect for full-time feeding or supplementing breast milk.
TRUSTED NUTRITION FOR COMBO FEEDING: With key nutrients for growing babies, Enfamil Optimum gives parents the flexibility to supplement breastfeeding with our closest formula to breast milk.
NO ARTIFICIAL ADDITIVES & NON-GMO: Has clinically-tested, non-GMO ingredients. Free from artificial growth hormones, colors, and flavors. Enfamil Optimum does not contain high fructose corn syrup and is made with milk sourced from the United States. Optimum is premium baby formula for infants through 12 months of age.
PEDIATRICIAN & PARENT TRUSTED: Enfamil is the #1 trusted infant formula brand by pediatricians* and parents, making Optimum baby formula a reliable choice for growing families.
JOIN ENFAMIL FAMILY BEGINNINGS & EARN REWARDS: Sign up for Enfamil Family Beginnings to enjoy exclusive savings, expert tips, and personalized support—plus earn rewards with every eligible purchase.
CHOOSE A CASE PACK FOR ADDED CONVENIENCE: Stock up with a case pack of Enfamil formula to help ensure you’re always prepared—ideal for regular feedings and busy routines.
7 reviews for Enfamil Optimum (Enspire), Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin and Brain-Supporting DHA Baby Formula, Powder 20.5 Oz Tub
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$46.87
James –
Great product and good price
We use this formula from birth, baby likes it and the price here especially with baby rigister discount is great!It says immune added, Hope it protect newborn and little baby
Labmom –
Great formula — gentle on baby’s tummy and mixes well
We’ve been using Enfamil Optimum for our baby and it’s been working really well. No issues with gas, spit-up, or tummy discomfort — which was a huge relief finding our go to formula on the first try.It mixes smoothly (no weird clumps), and our baby took to the taste without any fuss. It also seems to keep them full and content between feedings.Honestly, it’s just been a great fit for us. Peace of mind knowing baby is getting good nutrition and it agrees with their system. Definitely recommend trying it if you’re looking for a quality formula that’s easy on sensitive tummies.
Kenny Ngo –
Easy mixing!!
Great milk for my 2 boys. Zero issues with over gassing compared to the yellow.Easy mix and dissolves quickly.So far my boys have been growing healthy, smart and strong!
Cole Jordan –
Pricey but Great!
Both of my babies have thrived on this formula and done so well on it. We accidentally switched formulas from a Similac to this cold turkey on one of my babies (miscommunication with husband) and thankfully, he did just fine. No issues at all. Way more pricey than some formulas but I think its the worth the cost- especially if you wait for sales or use coupons.
What? –
Strong and healthy baby approved!!
My baby is 9 months old and has done amazing on this formula. No upset stomach. No constipation. No gas. She is a very easy baby. I think she’s trying to trick us into having baby #5 😂. I had one person basically tell me all formula was the same and it made no difference but then was really impressed by how strong and advanced my baby was. Idk I feel pretty good when I get proper nutrition. My baby was hardly sick WITH 3 school aged kids in the house. When she did get sick it was very short. She was able to fight it off quickly. I highly recommend this formula. Best wishes and congratulations on your new babies!!! 😘
@mazon is why I’m broke! –
Worth the premium cost, do sub and save to get a few bucks off, youw ill be going thru it anyway!
Best baby formula in my opinion. We tried the regular gold enfamil too which was fine but wanted mroe good stuff so thats why we changed… i think its worth the extra cost. do subscribe and save to get a few bucks cheaper then usual since you will be using it anyway. glad to be using this!
Jarret –
If you can afford it this is the winner.
Let me start by saying this formula is likely not the “best tasting” one out there. “Best tasting” when it comes to food is often the worst when it comes to nutrition. If you’re concerned about taste/smell this formula is probably not for you. I personally am un-bothered by the smell and only read the nutritional label when making my choice. If you’re concerned about the quality of ingredients, don’t want an obese child, and want to give your kid the best nutritional formula the US has to offer…. This product is for you.Secondly, I highly recommend ordering the refill packs on Amazon. Get your initial plastic tub from the grocery store then refill it the $55 box from Amazon. It’s cheaper and you don’t have to worry about seals being broken.This stuff is expensive…. But it helped develop my thriving 10-month-old who is talking, laughing, smiling, communicating, and hitting all of her physical milestones with ease. She was born 5 weeks early and we worried about her mental development. She was tiny and behind other babies at first in her milestones. Since my wife breastfed and could never keep up, this was initially recommended by our pediatrician to help supplement and eventually transition from breast milk. The lactoferrin and MFGM are the special ingredients along with lactose being it’s only sweetener instead of corn syrup. The MFGM makes a big difference in mental development while the lactoferrin helps develop a healthy gut (which attributes to the loads of parents saying this is the only thing their little ones can keep down). These are the only two ingredients that set it apart from traditional formulas… and they truly make a world of difference. This stuff is great. If it is just a little too expensive check out Enfamil NeuroPro… Which is basically the same thing just minus the Lactoferrin (it still contains the brain developing MFGM). Hopefully next time our next child decides to stay in the belly full-term, the breastfeeding starts off on the right foot and continues through one year. If not, I won’t think twice before using Enfamil Enspire again. It’s truly a no-brainer and we are so grateful to Enfamil for developing this incredible formula.